Workalicious reader and architect Jeremy Levine sends in the story of his home office for himself and his wife. Jeremy has suspended his desk and shelving from threaded rod hung from the roof rafters above. If he was using a mobile desk this would be ideal as their would be no obstructions to rolling the mobile surface under the computer desk. They call this the Mondrian Desk System. The surfaces can adjust up and down on the threaded rods.
Here's the home offices I designed for myself and my wife. Both offices feature variations on what I call the same Mondrian Desk System: constructed of veneer ply (clear, black, and red) all of the horizontal elements, desk and shelves, adjust up and down the support rods which are hung from the ceiling leaving the area under the desk clear. The keyboard tray and mouse pad slide out on hidden glider tracks. Secondary shelves rotate around the rods for mouse pads, speakers, etc. Both offices use a a concealed system hidden under the floor. Concealed trap doors in the floor are open by a foot pedal revealing a hidden storage room. The doors opens up in sections using the same pneumatic arms that hold open car hoods. The doors swing clear under the desk which hangs from the ceiling n threaded rods. Stairs descend 5 feet below to the storage area under the entire room.